Regulation of human pulmonary surfactant protein gene expression by 1alpha,25-dihydroxyvitamin D3.

  title={Regulation of human pulmonary surfactant protein gene expression by 1alpha,25-dihydroxyvitamin D3.},
  author={Sarabjit S Phokela and Sara Peleg and Fernando R. Moya and Joseph L. Alcorn},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={289 4},
1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] has been reported to stimulate lung maturity, alveolar type II cell differentiation, and pulmonary surfactant synthesis in rat lung. We hypothesized that 1,25(OH)(2)D(3) stimulates expression of surfactant protein-A (SP-A), SP-B, and SP-C in human fetal lung and type II cells. We found that immunoreactive vitamin D receptor was detectable in fetal lung tissue and type II cells only when incubated with 1,25(OH)(2)D(3). 1,25(OH)(2)D(3… 

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