Regulation of human p53 activity and cell localization by alternative splicing.

@article{Ghosh2004RegulationOH,
  title={Regulation of human p53 activity and cell localization by alternative splicing.},
  author={Anirban Ghosh and Deborah Stewart and Greg Matlashewski},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 18},
  pages={7987-97}
}
The development of cancer is a multistep process involving mutations in proto-oncogenes, tumor suppressor genes, and other genes which control cell proliferation, telomere stability, angiogenesis, and other complex traits. Despite this complexity, the cellular pathways controlled by the p53 tumor suppressor protein are compromised in most, if not all, cancers. In normal cells, p53 controls cell proliferation, senescence, and/or mediates apoptosis in response to stress, cell damage, or ectopic… CONTINUE READING

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