Regulation of human organic anion transporter 1 by ANG II: involvement of protein kinase Calpha.

@article{Li2009RegulationOH,
  title={Regulation of human organic anion transporter 1 by ANG II: involvement of protein kinase Calpha.},
  author={Shanshan Li and Peng Duan and Guofeng You},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2009},
  volume={296 2},
  pages={E378-83}
}
Human organic anion transporter 1 (hOAT1) belongs to a family of organic anion transporters that play critical roles in the body disposition of clinically important drugs, including anti-human immunodeficiency virus therapeutics, anti-tumor drugs, antibiotics, antihypertensives, and anti-inflammatories. hOAT1 is abundantly expressed in the kidney. In the current study, we examined the regulation of hOAT1 by ANG II in kidney COS-7 cells. ANG II induced a concentration- and time-dependent… CONTINUE READING
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Protein kinase C regulation of organic anion transport in renal proximal tubule

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