Regulation of human microsomal epoxide hydrolase gene (EPHX1) expression by the transcription factor GATA-4.

@article{Zhu2004RegulationOH,
  title={Regulation of human microsomal epoxide hydrolase gene (EPHX1) expression by the transcription factor GATA-4.},
  author={Qin-shi Zhu and B. Qian and Daniel L{\'e}vy},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1676 3},
  pages={251-60}
}
Microsomal epoxide hydrolase (mEH) is a bifunctional protein that plays a crucial role in the metabolism of numerous xenobiotics as well as in mediating the hepatic sodium-dependent uptake of bile acids that are involved in numerous physiological processes including the regulation of cholesterol metabolism. The transcription factors and nuclear receptors that control the constitutive and inducible expression of the mEH gene (EPHX1), however, have not been described. To characterize these… CONTINUE READING

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