Regulation of human metabolism by hypoxia-inducible factor.

@article{Formenti2010RegulationOH,
  title={Regulation of human metabolism by hypoxia-inducible factor.},
  author={Federico Formenti and Dumitru Constantin-Teodosiu and Yaso Emmanuel and J. Cheeseman and Keith L. Dorrington and Lindsay M. Edwards and Sandy M. Humphreys and Terence R. J. Lappin and Mary Frances McMullin and Christopher J. McNamara and Wendy Mills and John A. Murphy and David F O'connor and Melanie J. Percy and Peter J Ratcliffe and Thomas G Smith and Marilyn Treacy and Keith N. Frayn and Paul L Greenhaff and Fredrik Karpe and Kieran Clarke and Peter A. Robbins},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 28},
  pages={
          12722-7
        }
}
The hypoxia-inducible factor (HIF) family of transcription factors directs a coordinated cellular response to hypoxia that includes the transcriptional regulation of a number of metabolic enzymes. Chuvash polycythemia (CP) is an autosomal recessive human disorder in which the regulatory degradation of HIF is impaired, resulting in elevated levels of HIF at normal oxygen tensions. Apart from the polycythemia, CP patients have marked abnormalities of cardiopulmonary function. No studies of… CONTINUE READING

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SHOWING 1-10 OF 65 REFERENCES

HIF-1alpha in endurance training: suppression of oxidative metabolism.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2007
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice

J Cantley
  • J Clin Invest
  • 2009