Regulation of human involucrin promoter activity by novel protein kinase C isoforms.

@article{Efimova2000RegulationOH,
  title={Regulation of human involucrin promoter activity by novel protein kinase C isoforms.},
  author={Tatiana Efimova and Richard L Eckert},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 3},
  pages={1601-7}
}
Human involucrin (hINV) mRNA level and promoter activity increase when keratinocytes are treated with the differentiating agent, 12-O-tetradecanoylphorbol-13-acetate (TPA). This response is mediated via a p38 mitogen-activated protein kinase-dependent pathway that targets activator protein 1 (Efimova, T., LaCelle, P. T. , Welter, J. F., and Eckert, R. L. (1998) J. Biol. Chem. 273, 24387-24395). In the present study we examine the role of various PKC isoforms in this regulation. Transfection of… CONTINUE READING

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