Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB

@article{Oetjen2003RegulationOH,
  title={Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB},
  author={Elke Oetjen and Daniela Grapentin and Roland Blume and Michael Seeger and Doris Krause and Anke Eggers and Willhart Knepel},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2003},
  volume={367},
  pages={227-236}
}
Cyclosporin A and tacrolimus are important immunosuppressive drugs. They share a diabetogenic action as one of their most serious adverse effects. In a single study, tacrolimus (100 nM) inhibited human insulin gene transcription in the β-cell line HIT. Using transfections of a human insulin-reporter gene into HIT cells, the present study shows that this inhibition is seen only at high concentrations of tacrolimus and is not caused by cyclosporin A. However, after stimulation by the major… CONTINUE READING

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