Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier.

  title={Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier.},
  author={Jurgen Karczewski and Freddy J. Troost and Irene B. M. Konings and Jan Dekker and Michiel Kleerebezem and Robert Jan Brummer and Jerry M Wells},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={298 6},
  • J. KarczewskiF. Troost J. Wells
  • Published 1 June 2010
  • Biology, Medicine
  • American journal of physiology. Gastrointestinal and liver physiology
Lactobacillus plantarum, a commensal bacterium of humans, has been proposed to enhance the intestinal barrier, which is compromised in a number of intestinal disorders. To study the effect of L. plantarum strain WCFS1 on human barrier function, healthy subjects were administered L. plantarum or placebo in the duodenum for 6 h by means of a feeding catheter. The scaffold protein zonula occludens (ZO)-1 and transmembrane protein occludin were found to be significantly increased in the vicinity of… 

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