Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4.

@article{Luis2011RegulationOH,
  title={Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4.},
  author={Nuno Miguel Luis and Lluis Morey and Stefania Mejetta and Gloria Pascual and Peggy Janich and Bernd Kuebler and Luca Cozutto and Guglielmo Roma and Elisabete Nascimento and Michaela Frye and Luciano Di Croce and Salvador Aznar Benitah},
  journal={Cell stem cell},
  year={2011},
  volume={9 3},
  pages={233-46}
}
Human epidermal stem cells transit from a slow cycling to an actively proliferating state to contribute to homeostasis. Both stem cell states differ in their cell cycle profiles but must remain guarded from differentiation and senescence. Here we show that Cbx4, a Polycomb Repressive Complex 1 (PRC1)-associated protein, maintains human epidermal stem cells as slow-cycling and undifferentiated, while protecting them from senescence. Interestingly, abrogating the polycomb activity of Cbx4 impairs… CONTINUE READING

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