Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3.

@article{Hawker2007RegulationOH,
  title={Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3.},
  author={Nathaniel P Hawker and Sally D Pennypacker and Sandra M Chang and Daniel D Bikle},
  journal={The Journal of investigative dermatology},
  year={2007},
  volume={127 4},
  pages={874-80}
}
It has long been known that the active metabolite of vitamin D, 1,25 dihydroxyvitamin D(3), stimulates differentiation and inhibits proliferation in epidermal keratinocytes through interaction with the vitamin D receptor (VDR). VDR functions through the coordinate binding of vitamin D response elements in the DNA and specific coactivator proteins which help to initiate transcription. It was recently observed that VDR binds to two major coactivator complexes, DRIP (VDR-interacting protein) and… CONTINUE READING

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