Regulation of human eosinophil degranulation and activation by endogenous phospholipase A2.

@article{White1993RegulationOH,
  title={Regulation of human eosinophil degranulation and activation by endogenous phospholipase A2.},
  author={Steven R White and Mary E Strek and G V Kulp and Stephen M. Spaethe and R M Burch and Scott P. Neeley and Alan R. Leff},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={91 5},
  pages={2118-25}
}
The unique granular proteins of eosinophils may have a pathogenetic role in asthma and in the defense against parasitic infestations. However, the mechanisms regulating eosinophil degranulation are largely unknown. We examined the hypothesis that release of these proteins is regulated by endogenous activation of phospholipase A2. Human eosinophils (HE) were isolated from the peripheral blood of 42 subjects either by Percoll density separation or by negative-selection immunomagnetic… CONTINUE READING