Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin.

@article{Pera2004RegulationOH,
  title={Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin.},
  author={Martin F Pera and J{\'e}ssica Cristina Bilizario Noguerol Andrade and Souheir Houssami and Benjamin E. Reubinoff and Alan Trounson and Edouard G. Stanley and Dorien Ward-van Oostwaard and Christine L Mummery},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 7},
  pages={1269-80}
}
Human embryonic stem cells differentiate spontaneously in vitro into a range of cell types, and they frequently give rise to cells with the properties of extra-embryonic endoderm. We show here that endogenous signaling by bone morphogenetic protein-2 controls the differentiation of embryonic stem cells into this lineage. Treatment of embryonic stem cell cultures with the bone morphogenetic protein antagonist noggin blocks this form of differentiation and induces the appearance of a novel cell… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
144 Citations
36 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 144 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…