Regulation of human cytolytic lymphocyte responses by interleukin-12.

  title={Regulation of human cytolytic lymphocyte responses by interleukin-12.},
  author={Maurice K. Gately and A G Wolitzky and Patricia K. Quinn and Richard A. Chizzonite},
  journal={Cellular immunology},
  volume={143 1},
IL-12 is a heterodimeric cytokine which has been shown to cause the proliferation of activated T and NK cells, to enhance the lytic activity of NK cells, and to induce IFN-gamma production by resting and activated T and NK cells. We previously reported that IL-12 could synergize with IL-2 to activate human LAK cells in the presence of hydrocortisone but that IL-12 alone was inactive. We herein show that in the absence of hydrocortisone, IL-12 by itself can activate human LAK cells. IL-12… CONTINUE READING


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