Regulation of human alveolar macrophage- and blood monocyte-derived interleukin-8 by prostaglandin E2 and dexamethasone.

@article{Standiford1992RegulationOH,
  title={Regulation of human alveolar macrophage- and blood monocyte-derived interleukin-8 by prostaglandin E2 and dexamethasone.},
  author={Theodore J Standiford and Steven L. Kunkel and Mark W. Rolfe and Holly L. Evanoff and Richard M Allen and Robert M. Strieter},
  journal={American journal of respiratory cell and molecular biology},
  year={1992},
  volume={6 1},
  pages={
          75-81
        }
}
Mononuclear phagocytes are important immune effector cells that play a fundamental role in cellular immunity. In addition to their antigen-presenting and phagocytic activities, monocytes/macrophages produce a vast array of regulatory and chemotactic cytokines. Interleukin-8 (IL-8), a potent neutrophil-activating and chemotactic peptide, is produced in large quantities by mononuclear phagocytes and may be an important mediator of local and systemic inflammatory events. In this investigation, we… CONTINUE READING
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