Regulation of human alcohol dehydrogenase genes.

  title={Regulation of human alcohol dehydrogenase genes.},
  author={Howard J. Edenberg and C J Brown},
  volume={2 5},
This review focuses upon the regulation of the three human class I alcohol dehydrogenase genes, ADH1, ADH2 and ADH3. These closely related genes are expressed at high levels in liver, and at different levels in other tissues. Multiple cis-acting sequences to which nuclear proteins bind have been mapped, and transcription factors that can bind to these sequences have been identified; these include C/EBP alpha, Sp1, USF, HNF1, CTF/NF1, the glucocorticoid receptor, and RAR alpha. There are… CONTINUE READING

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