Regulation of human PDE5A2 intronic promoter by cAMP and cGMP: identification of a critical Sp1-binding site.

@article{Lin2001RegulationOH,
  title={Regulation of human PDE5A2 intronic promoter by cAMP and cGMP: identification of a critical Sp1-binding site.},
  author={Chin-Yu Lin and Sylvia Chow and Adrian Lau and Ran Tu and Tom F. Lue},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={280 3},
  pages={693-9}
}
PDE5A gene encodes type 5 phosphodiesterase (PDE5), the principal cGMP-catalyzing enzyme in the penis and the primary target of sildenafil (Viagra). We have previously reported the isolation of three alternatively spliced PDE5A isoforms in humans. We also reported the identification of three corresponding alternative first exons and an intronic promoter in… CONTINUE READING