Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase.

@article{Huang2001RegulationOH,
  title={Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase.},
  author={Pingbo Huang and J Liu and Anke Di and N C Robinson and Mark W Musch and Marcia A. Kaetzel and Deborah J. Nelson},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 23},
  pages={20093-100}
}
The multifunctional calcium/calmodulin-dependent protein kinase II, CaMKII, has been shown to regulate chloride movement and cellular function in both excitable and non-excitable cells. We show that the plasma membrane expression of a member of the ClC family of Cl(-) channels, human CLC-3 (hCLC-3), a 90-kDa protein, is regulated by CaMKII. We cloned the full-length hCLC-3 gene from the human colonic tumor cell line T84, previously shown to express a CaMKII-activated Cl(-) conductance (I(Cl… CONTINUE READING
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