Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha.

@article{Stayrook2008RegulationOH,
  title={Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha.},
  author={Keith R. Stayrook and Pamela M. Rogers and Rajesh S. Savkur and Yongjun Wang and Chen Su and G{\'a}bor Varga and Xin Bu and Tao Wei and Sunil Nagpal and Xiaole Shirley Liu and Thomas P Burris},
  journal={Molecular pharmacology},
  year={2008},
  volume={73 2},
  pages={607-12}
}
Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism. Utilization of a hidden Markov model for predictive modeling of nuclear hormone receptor response elements coupled with chromatin immunoprecipitation/microarray technology revealed a… CONTINUE READING