Regulation of hormone-sensitive calcium influx by the adenylyl cyclase system in renal epithelial cells.

@article{Kitamura1994RegulationOH,
  title={Regulation of hormone-sensitive calcium influx by the adenylyl cyclase system in renal epithelial cells.},
  author={Kuniaki Kitamura and Richard Tyler Miller},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 1},
  pages={328-36}
}
To study signaling pathways regulated by alpha s and alpha i1 in renal epithelial cells, we expressed mutant, activated forms of alpha s and alpha i1 in a continuous proximal tubule cell line (MCT cells). alpha sQ227L increased cAMP production, and alpha ilQ204L reduced forskolin-sensitive cAMP production. alpha ilQ204L increased and alpha sQ227L decreased bradykinin-induced Ca influx across the cell membrane, but neither mutant affected bradykinin-stimulated intracellular Ca release or basal… CONTINUE READING

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