Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.

  title={Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.},
  author={Kyosuke Nakamura and Akihiro Kato and Junya Kobayashi and Hiromi Yanagihara and Shuichi Sakamoto and Douglas V N P Oliveira and Mikio Shimada and Hiroshi Tauchi and Hidekazu Suzuki and Satoshi Tashiro and L. Q. Zou and Kenshi Komatsu},
  journal={Molecular cell},
  volume={41 5},
The E3 ubiquitin ligase RNF20 regulates chromatin structure by monoubiquitinating histone H2B in transcription. Here, we show that RNF20 is localized to double-stranded DNA breaks (DSBs) independently of H2AX and is required for the DSB-induced H2B ubiquitination. In addition, RNF20 is required for the methylation of H3K4 at DSBs and the recruitment of the chromatin-remodeling factor SNF2h. Depletion of RNF20, depletion of SNF2h, or expression of the H2B mutant lacking the ubiquitination site… CONTINUE READING
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