Regulation of high-affinity glutamate transport by amino acid deprivation and hyperosmotic stress.

@article{McGivan1999RegulationOH,
  title={Regulation of high-affinity glutamate transport by amino acid deprivation and hyperosmotic stress.},
  author={John D. McGivan and Benjamin Nicholson},
  journal={American journal of physiology. Renal physiology},
  year={1999},
  volume={277 4},
  pages={F498-F500}
}
High-affinity glutamate transport activity is induced by stress in NBL-1 cells. Exposure of cells to hyperosmotic medium led to an induction of the EAAC1 glutamate transporter, preceded by a large increase in EAAC1 mRNA levels. Culture of cells in amino acid-free medium also caused a protein synthesis-dependent increase in glutamate transport activity, but this was not accompanied by an increase of either EAAC1 mRNA or protein. Indirect evidence suggests that the increase in EAAC1 activity in… CONTINUE READING

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