Regulation of hexokinase binding to VDAC.

  title={Regulation of hexokinase binding to VDAC.},
  author={John G. Pastorino and Jan B. Hoek},
  journal={Journal of bioenergetics and biomembranes},
  volume={40 3},
Hexokinase isoforms I and II bind to mitochondrial outer membranes in large part by interacting with the outer membrane voltage-dependent anion channel (VDAC). This interaction results in a shift in the susceptibility of mitochondria to pro-apoptotic signals that are mediated through Bcl2-family proteins. The upregulation of hexokinase II expression in tumor cells is thought to provide both a metabolic benefit and an apoptosis suppressive capacity that gives the cell a growth advantage and… CONTINUE READING
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