Regulation of hexokinase binding to VDAC.

@article{Pastorino2008RegulationOH,
  title={Regulation of hexokinase binding to VDAC.},
  author={John G. Pastorino and Jan B. Hoek},
  journal={Journal of bioenergetics and biomembranes},
  year={2008},
  volume={40 3},
  pages={171-82}
}
Hexokinase isoforms I and II bind to mitochondrial outer membranes in large part by interacting with the outer membrane voltage-dependent anion channel (VDAC). This interaction results in a shift in the susceptibility of mitochondria to pro-apoptotic signals that are mediated through Bcl2-family proteins. The upregulation of hexokinase II expression in tumor cells is thought to provide both a metabolic benefit and an apoptosis suppressive capacity that gives the cell a growth advantage and… CONTINUE READING
Highly Influential
This paper has highly influenced 19 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
129 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 129 extracted citations

Similar Papers

Loading similar papers…