Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages.

  title={Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages.},
  author={Xiao-bing Liu and N Huynh Nguyen and Kimberly D Marquess and Funmei Yang and David J. Haile},
  journal={Blood cells, molecules & diseases},
  volume={35 1},
Acute and chronic inflammatory states are associated with many changes in intracellular iron metabolism including sequestration of iron in the mononuclear-phagocyte system (MPS) and a decline in serum iron. Previous work in rodent models of acute inflammation has demonstrated inflammation-induced downregulation of intestinal and MPS iron exporter, ferroportin 1, mRNA and protein. In addition, these models have also demonstrated hepatic induction of mRNA of the small 25 amino acid peptide… CONTINUE READING


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