Regulation of hepatocyte glutathione by amino acid precursors and cAMP in protein-energy malnourished rats.

@article{Goss1994RegulationOH,
  title={Regulation of hepatocyte glutathione by amino acid precursors and cAMP in protein-energy malnourished rats.},
  author={Phil Michael Goss and Tammy M. Bray and Laura E Nagy},
  journal={The Journal of nutrition},
  year={1994},
  volume={124 3},
  pages={
          323-30
        }
}
Hepatic glutathione concentration is decreased in protein-energy malnutrition. Malnourished rats are able to replenish hepatic glutathione after oral supplementation with L-2-oxothiazolidine-4-carboxylate, a cysteine pro-drug, to levels that are higher than in control rats. These results suggest that, even if a normal amount of amino acids for glutathione synthesis is provided, homeostatic control of glutathione concentration after protein-energy malnutrition is abnormal. The rate limiting… CONTINUE READING