Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors.

@article{Gaa2002RegulationOH,
  title={Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors.},
  author={Marianna D. A. Gaça and Xiaoying Zhou and Robert Christopher Benyon},
  journal={Journal of hepatology},
  year={2002},
  volume={36 3},
  pages={362-9}
}
BACKGROUND/AIMS Thrombin and MC tryptase, which are agonists for proteinase-activated receptors-1 and -2, respectively, are both increased in injured liver. We have examined if rat stellate cells express these receptors and if receptor agonists influence stellate cell activation. METHODS Expression of mRNA for proteinase activated receptors-1 and -2 were… CONTINUE READING