Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2.

@article{Wang2004RegulationOH,
  title={Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2.},
  author={Xuemin Wang and Xiaoli Tang and Xiaoming Gong and Efsevia Albanis and Scott L Friedman and Zixu Mao},
  journal={Gastroenterology},
  year={2004},
  volume={127 4},
  pages={1174-88}
}
BACKGROUND & AIMS Hepatic stellate cells (HSCs) undergo activation during the development of liver fibrosis. Transcriptional regulation plays a key role in this process. We studied the role of transcription factor myocyte enhancer factor 2 (MEF2) during HSC activation. METHODS Culture of HSCs isolated from rat liver on plastic dishes and HSC-T6 on a basement membrane-like matrix were used as models of HSC activation and deactivation, respectively. The expression and activity of MEF2 were… CONTINUE READING
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