Regulation of hepatic glutathione synthesis: current concepts and controversies

@article{Lu1999RegulationOH,
  title={Regulation of hepatic glutathione synthesis: current concepts and controversies},
  author={Shelly C. Lu},
  journal={The FASEB Journal},
  year={1999},
  volume={13},
  pages={1169 - 1183}
}
Glutathione (GSH) is an important intracellular peptide with multiple functions ranging from antioxidant defense to modulation of cell proliferation. GSH is synthesized in the cytosol of all mammalian cells in a tightly regulated manner. The major determinants of GSH synthesis are the availability of cysteine, the sulfur amino acid precursor, and the activity of the rate‐limiting enzyme, γ‐glutamylcysteine synthetase (GCS). In the liver, major factors that determine the availability of cysteine… 

Regulation of glutathione synthesis.

  • Shelly C. Lu
  • Biology, Chemistry
    Molecular aspects of medicine
  • 2009

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