Regulation of hepatic glutathione metabolism and its role in hepatotoxicity.

  • M. Kretzschmar
  • Published 1996 in
    Experimental and toxicologic pathology : official…


The regulation of hepatic glutathione (GSH) metabolism have been reviewed. Key steps in the regulation of hepatic GSH are GSH biosynthesis, the GSH-redox-cycle, the cystathionine pathway, and the carrier-mediated export processes. Possible influences of xenobiotics on these different pathways are discussed. GSH fulfills several essential functions… (More)


Cite this paper

@article{Kretzschmar1996RegulationOH, title={Regulation of hepatic glutathione metabolism and its role in hepatotoxicity.}, author={M. Kretzschmar}, journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie}, year={1996}, volume={48 5}, pages={439-46} }