Regulation of hepatic glucokinase gene expression. Role of carbohydrates, and glucocorticoid and thyroid hormones.

@article{Minderop1987RegulationOH,
  title={Regulation of hepatic glucokinase gene expression. Role of carbohydrates, and glucocorticoid and thyroid hormones.},
  author={Raphaela Minderop and W. H{\"o}ppner and Hans Joachim Seitz},
  journal={European journal of biochemistry},
  year={1987},
  volume={164 1},
  pages={
          181-7
        }
}
The present study investigates the effect of thyroid and glucocorticoid hormones on the induction of hepatic glucokinase mRNA activity, enzyme synthesis and activity in starved/refed adrenalectomized, thyroidectomized and intact rats. In intact rats glucose refeeding resulted within 2 h in a more than tenfold increase in the functional messenger, followed by a corresponding increase in glucokinase synthesis and, a little later, in enzyme activity. Glucokinase mRNA and synthesis remained… CONTINUE READING