Regulation of heparin binding-epidermal growth factor like growth factor gene expression by LDL and oxidized-LDL in rat mesangial cells.

@article{Tan1994RegulationOH,
  title={Regulation of heparin binding-epidermal growth factor like growth factor gene expression by LDL and oxidized-LDL in rat mesangial cells.},
  author={Ma. Carmen S. Tan and Yong Jun Lee and Seog Jun Shin and Ju- He Tsai},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={202 2},
  pages={
          1001-8
        }
}
The present study was to determine whether low-density lipoprotein (LDL) and oxidized LDL (Ox-LDL) modulate the heparin binding-epidermal growth factor like growth factor (HB-EGF) gene expression in rat mesangial cells (RMC). Using Northern blot analysis, LDL and Ox-LDL stimulated the expression of RMC HB-EGF mRNA in a time- and concentration-dependent manner, and the stimulatory effect of Ox-LDL lasted longer than LDL. In addition, a protein kinase C (PKC) inhibitor-staurosporine and a PKC… CONTINUE READING
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