Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury.

@article{Lee1996RegulationOH,
  title={Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury.},
  author={Peiyu Lee and Jawed Alam and S L Sylvester and Nikil Inamdar and Leo E Otterbein and Augustine M. K. Choi},
  journal={American journal of respiratory cell and molecular biology},
  year={1996},
  volume={14 6},
  pages={556-68}
}
Using hyperoxia as a model of oxidant-induced lung injury in the rat, we explored the regulation of heme oxygenase-1 (HO-1) expression in vivo and in vitro. We demonstrate marked increase of HO-1 messenger ribonucleic acid (mRNA) levels in rat lungs after hyperoxia. Increased HO-1 mRNA expression correlated with increased HO-1 protein and enzyme activity. Immunohistochemical studies of the rat lung after hyperoxia showed increased HO-1 expression in a variety of cell types, including the… CONTINUE READING

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