Regulation of hematopoietic stem cell self-renewal.

  title={Regulation of hematopoietic stem cell self-renewal.},
  author={Tannishtha Reya},
  journal={Recent progress in hormone research},
Every day, billions of new blood cells are produced in the body, each one derived from a hematopoietic stem cell (HSC). Because most mature blood stem cells have a limited life span, the ability of HSCs to perpetuate themselves through self-renewal and generate new blood cells for the lifetime of an organism is critical to sustaining life. A key problem in hematopoietic stem cell biology is how HSC self-renewal is regulated. Recent evidence suggests that signaling pathways classically involved… CONTINUE READING


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