Regulation of heat shock protein 72 kDa and 90 kDa in human breast cancer MDA-MB-231 cells

@article{Kiang2000RegulationOH,
  title={Regulation of heat shock protein 72 kDa and 90 kDa in human breast cancer MDA-MB-231 cells},
  author={Juliann G Kiang and Irene D. Gist and George C Tsokos},
  journal={Molecular and Cellular Biochemistry},
  year={2000},
  volume={204},
  pages={169-178}
}
It has been shown that expression of HSPs can negatively regulate the effectiveness of cytotoxic drugs. In this study, we conducted experiments to study the regulation of expression of heat shock proteins (HSPs) in human breast cancer MDA-MB-231 cells. Using [35S]methionine incorporation and Western immunoblots, we established that heat shock increased production of HSP-72 and -90. Cells exposed to 44°C for 20 min displayed increased expression of HSP-72 and -90, that reached a maximum 3-7 h… CONTINUE READING

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