Regulation of heartbeat in Lymnaea by motoneurons containing FMRFamide-like peptides.

  title={Regulation of heartbeat in Lymnaea by motoneurons containing FMRFamide-like peptides.},
  author={K J Buckett and Michael Peters and Graham J. Dockray and Jan van Minnen and Paul R. Benjamin},
  journal={Journal of neurophysiology},
  volume={63 6},
1. Intracellular stimulation of single neurons in the Lymnaea CNS was carried out to identify heart motoneurons. 2. Two of the identified motoneurons, the E heart excitor (Ehe) cells, were shown to contain Phe-Met-Arg-Phe-NH2 (FMRFamide)-like peptides by immunocytochemical staining of dye-marked neurons and by radioimmunoassay (RIA) applied to extracts of single dissected cells. 3. Bursts of spikes in the Ehe cells increased heart rate, beat amplitude and muscle tonus. This response was… CONTINUE READING

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