Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide.

@article{Yong2011RegulationOH,
  title={Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide.},
  author={Qian-Chen Yong and Jia Ling Cheong and Fei Hua and Lih-Wen Deng and Yok Moi Khoo and How-sung Lee and Alexis Perry and Mark Wood and Matthew Whiteman and Jin-Song Bian},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={14 11},
  pages={2081-91}
}
Both nitric oxide (NO) and hydrogen sulfide (H(2)S) are two important gaseous mediators regulating heart function. The present study examined the interaction between these two biological gases and its role in the heart. We found that l-arginine, a substrate of NO synthase, decreased the amplitudes of myocyte contraction and electrically induced calcium transients. Sodium hydrogen sulfide (an H(2)S donor), which alone had minor effect, reversed the negative inotropic effects of l-arginine. The… CONTINUE READING

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