Regulation of growth and differentiation by phorbol esters and the mechanism of tumor promotion.

@article{Lotem1982RegulationOG,
  title={Regulation of growth and differentiation by phorbol esters and the mechanism of tumor promotion.},
  author={Joseph Lotem and Leo Sachs},
  journal={Carcinogenesis; a comprehensive survey},
  year={1982},
  volume={7},
  pages={385-90}
}
Our studies on the growth and differentiation of normal and malignant myeloid cells have shown that tumor-promoting, but not nonpromoting, phorbol esters can induce the production of an specifically increase cell susceptibility to the normal myeloid inducers of growth and differentiation, the macrophage- and granulocyte-inducing proteins MGI. In some clones… CONTINUE READING