Regulation of gonadotropin secretion and puberty onset by neuromedin U.

  title={Regulation of gonadotropin secretion and puberty onset by neuromedin U.},
  author={Yoshihiko Fukue and Takahiro Sato and Hitoshi Teranishi and Reiko Hanada and Tomoko Tazawa Takahashi and Yoshiki Nakashima and Masayasu Kojima},
  journal={FEBS letters},
  volume={580 14},
Neuromedin U (NMU), an anorexigenic peptide, was originally isolated from porcine spinal cord in 1985. As NMU is abundant in the anterior pituitary gland, we investigated the effects of NMU on gonadotropin secretion. Both NMU and its receptors, NMUR1 and NMUR2, were expressed in the pituitary gland. NMU suppressed LH and FSH releases from rat anterior pituitary cells. Moreover, NMU-deficient mice exhibit an early onset of vaginal opening. The LHbeta/FSHbeta ratio, which is an index of puberty… CONTINUE READING

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