Regulation of gonadotropin alpha subunit gene expression by dopamine D(2) receptor agonist in clonal mouse gonadotroph alphaT3-1 cells.

@article{Kanasaki2002RegulationOG,
  title={Regulation of gonadotropin alpha subunit gene expression by dopamine D(2) receptor agonist in clonal mouse gonadotroph alphaT3-1 cells.},
  author={Haruhiko Kanasaki and Toshie Yonehara and Yoko Yamada and Kentaro Takahashi and Kohkichi Hata and Rituto Fujiwaki and Hideyuki Yamamoto and Yusuke Takeuchi and Kohji Fukunaga and Eishichi Miyamoto and Kohji Miyazaki},
  journal={Biology of reproduction},
  year={2002},
  volume={67 4},
  pages={
          1218-24
        }
}
Pituitary prolactin biosynthesis is negatively regulated by hypothalamic dopamine through D(2) receptors in pituitary lactotrophs, but little is known about the direct effect of dopamine on gonadotrophs. In this study, the clonal gonadotroph-derived cell line, alphaT3-1, was used to examine whether gene expression of the pituitary gonadotropin alpha subunit, stimulated with GnRH or pituitary adenylate cyclase-activating polypeptide (PACAP), was controlled by dopamine D(2) receptor. Western… CONTINUE READING