Regulation of gonadotrophin-releasing hormone (GnRH) secretion by heme molecules: a regulatory role for carbon monoxide?

@article{Lamar1996RegulationOG,
  title={Regulation of gonadotrophin-releasing hormone (GnRH) secretion by heme molecules: a regulatory role for carbon monoxide?},
  author={C A Lamar and Virendra B. Mahesh and Darrell W Brann},
  journal={Endocrinology},
  year={1996},
  volume={137 2},
  pages={790-3}
}
Recent studies suggest that carbon monoxide (CO), which is produced in significant quantities in many brain regions including the hypothalamus, may function as a neurotransmitter. The purpose of the present study therefore was to access whether CO is capable of regulating the secretion of the hypothalamic releasing factor, gonadotropin-releasing hormone (GnRH). To this end, medial basal hypothalami were obtained from estrogen-primed ovariectomized adult rats and incubated in vitro for a 1 hour… CONTINUE READING