Regulation of glutaminase activity and glutamine metabolism.

  title={Regulation of glutaminase activity and glutamine metabolism.},
  author={Norman P. Curthoys and Malcolm Watford},
  journal={Annual review of nutrition},
Glutamine is synthesized primarily in skeletal muscle, lungs, and adipose tissue. Plasma glutamine plays an important role as a carrier of nitrogen, carbon, and energy between organs and is used for hepatic urea synthesis, for renal ammoniagenesis, for gluconeogenesis in both liver and kidney, and as a major respiratory fuel for many cells. The catabolism of glutamine is initiated by either of two isoforms of the mitochondrial glutaminase. Liver-type glutaminase is expressed only in periportal… CONTINUE READING
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