Regulation of glutamate transporters in astrocytes: Evidence for a relationship between transporter expression and astrocytic phenotype

@article{Zagami2005RegulationOG,
  title={Regulation of glutamate transporters in astrocytes: Evidence for a relationship between transporter expression and astrocytic phenotype},
  author={Chrissandra J. Zagami and Ross D. O’shea and C. L. Lau and Surindar S. Cheema and Philip M. Beart},
  journal={Neurotoxicity Research},
  year={2005},
  volume={7},
  pages={143-149}
}
The astrocytic glutamate transporters, EAAT1 and EAAT2, remove released L-glutamate from the synaptic milieu thereby maintaining normal excitatory transmission. EAAT dysfunction during the excitotoxicity and oxidative stress of neurological insults may involve homoeostatic mechanisms associated with astrocytic function. We investigated aspects of EAAT function and expression in concert with astrocytic phenotype in primary cultures of cortical astrocytes and mixed cells of the spinal cord. In… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Binding and transport of [ 3 H ] ( 2 S , 4 R )4methylglutamate , a new ligand for glutamate transporters , demonstrate labeling of EAAT 1 in cultured murine astrocytes

  • K Aprico
  • J . Neurosci . Res .
  • 2004

Glial glutamate

  • JY Chatton, PJ Magistretti, L Pellerin
  • 2003

Similar Papers

Loading similar papers…