Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.

@article{Loebrich2013RegulationOG,
  title={Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.},
  author={Sven Loebrich and Biljana Djukic and Zachary J Tong and Jeffrey Richard Cottrell and Gina G. Turrigiano and Elly Nedivi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 47},
  pages={
          E4548-56
        }
}
A key neuronal mechanism for adjusting excitatory synaptic strength is clathrin-mediated endocytosis of postsynaptic glutamate receptors (GluRs). The actin cytoskeleton is critical for clathrin-mediated endocytosis, yet we lack a mechanistic understanding of its interaction with the endocytic process and how it may be regulated. Here we show that F-actin in dendritic spines physically binds the synaptic nuclear envelope 1 gene product candidate plasticity gene 2 (CPG2) in a PKA-dependent manner… CONTINUE READING
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