Regulation of glucose transport by insulin: traffic control of GLUT4

  title={Regulation of glucose transport by insulin: traffic control of GLUT4},
  author={Dara Leto and A. Saltiel},
  journal={Nature Reviews Molecular Cell Biology},
  • Dara Leto, A. Saltiel
  • Published 2012
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • Despite daily fasting and feeding, plasma glucose levels are normally maintained within a narrow range owing to the hormones insulin and glucagon. Insulin increases glucose uptake into fat and muscle cells through the regulated trafficking of vesicles that contain glucose transporter type 4 (GLUT4). New insights into insulin signalling reveal that phosphorylation events initiated by the insulin receptor regulate key GLUT4 trafficking proteins, including small GTPases, tethering complexes and… CONTINUE READING
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