Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways.

@article{Blair1999RegulationOG,
  title={Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways.},
  author={Anne S Blair and Eric Hajduch and Gary J. Litherland and Harinder S Hundal},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 51},
  pages={36293-9}
}
We have investigated the cellular mechanisms that participate in reducing insulin sensitivity in response to increased oxidant stress in skeletal muscle. Measurement of glucose transport and glycogen synthesis in L6 myotubes showed that insulin stimulated both processes, by 2- and 5-fold, respectively. Acute (30 min) exposure of muscle cells to hydrogen peroxide (H(2)O(2)) blocked the hormonal activation of both these processes. Immunoblot analyses of cell lysates prepared after an acute… CONTINUE READING

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Insulin Signaling

  • M. Deak, A. D. Clifton, L. M. Lucocq, D. R. Alessi
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