Regulation of glucose metabolism in pancreatic islets.

  title={Regulation of glucose metabolism in pancreatic islets.},
  author={M D Trus and Walter S. Zawalich and Phillip T. Burch and Dana K. Berner and V A Weill and Franz M. Matschinsky},
  volume={30 11},
We evaluated the possible role of islet glucokinase in controlling the rate of islet glucose metabolism, and thereby the rate of glucose-induced insulin release. The activities of glucokinase, hexokinase, P-fructokinase, and glyceraldehyde-P dehydrogenase were quantitated in sonicated or isotonically homogenized islet preparations using pyridine nucleotide-dependent fluorometric assays. In sonicates, about 1/4 of the islet glucose phosphorylating activity was due to an enzyme with kinetic… CONTINUE READING
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