Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

@article{Zhou2011RegulationOG,
  title={Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction},
  author={Yingjiang Zhou and Justin Lee and Candace M Reno and Cheng Sun and Sang Won Park and Jason Chung and Jaemin Lee and Simon J Fisher and Morris F.WhiteM.F. White and Sudha B Biddinger and Umut Ozcan},
  journal={Nature Medicine},
  year={2011},
  volume={17},
  pages={356-365}
}
To date, the only known role of the spliced form of X-box–binding protein-1 (XBP-1s) in metabolic processes has been its ability to act as a transcription factor that regulates the expression of genes that increase the endoplasmic reticulum (ER) folding capacity, thereby improving insulin sensitivity. Here we show that XBP-1s interacts with the Forkhead box O1 (FoxO1) transcription factor and directs it toward proteasome-mediated degradation. Given this new insight, we tested modest hepatic… CONTINUE READING
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