Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity.

@article{Schmoll2000RegulationOG,
  title={Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity.},
  author={Dieter Schmoll and Kay S. Walker and Dario R Alessi and Rolf Grempler and A. R. Burchell and Shaodong Guo and R. {\'A}lvarez-Sala Walther and Terry G. Unterman},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 46},
  pages={36324-33}
}
Glucose-6-phosphatase plays an important role in the regulation of hepatic glucose production, and insulin suppresses glucose-6-phosphatase gene expression. Recent studies indicate that protein kinase B and Forkhead proteins contribute to insulin-regulated gene expression in the liver. Here, we examined the role of protein kinase B and Forkhead proteins in mediating effects of insulin on glucose-6-phosphatase promoter activity. Transient transfection studies with reporter gene constructs… CONTINUE READING
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