Regulation of glucocorticoid receptor protein and mRNA levels.

  title={Regulation of glucocorticoid receptor protein and mRNA levels.},
  author={Wayne V. Vedeckis and Marina B Ali and H Raymond Allen},
  journal={Cancer research},
  volume={49 8 Suppl},
The level of steroid receptors in target cells affects the responsiveness of the cell to the hormone. In mouse AtT-20 cells, it has been shown that chronic glucocorticoid treatment causes a down-regulation of glucocorticoid receptor (GR) levels (F. Svec and M. Rudis, J. Biol. Chem., 256:5984-5987, 1981). The current study shows that chronic hormone treatment reduces the amount of GR mRNA to about 50% of that in untreated cells. A combined treatment of the cells with an inhibitor of RNA… CONTINUE READING


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Glucocorticoid regulation of protooncogene expression and cellular prolif eration

  • W. V. Vedeekis, S. B. Eastman-Reks, LaPointe, C M., C. E. Reker
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