Regulation of glucocorticoid receptor function through assembly of a receptor-heat shock protein complex.

@article{Hutchison1993RegulationOG,
  title={Regulation of glucocorticoid receptor function through assembly of a receptor-heat shock protein complex.},
  author={K A Hutchison and L C Scherrer and M J Czar and Louis F. Stancato and Y H Chow and Richard L. Jove and William A. B. Pratt},
  journal={Annals of the New York Academy of Sciences},
  year={1993},
  volume={684},
  pages={35-48}
}
Incubation of immunopurified, hormone-free mouse glucocorticoid receptors with rabbit reticulocyte lysate results in ATP-dependent and monovalent cation-dependent assembly of the GR into a heterocomplex with hsp90, hsp70, and hsp56. Heterocomplex assembly is accompanied by conversion of the receptor from a form that does not bind steroid to a high affinity steroid-binding conformation. Reticulocyte lysate also promotes ATP-dependent dissociation of unliganded receptors from a prebound receptor… CONTINUE READING
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Role of heat shock proteins in steroid receptor function

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