Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors.

@article{Marty2005RegulationOG,
  title={Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors.},
  author={Nell Marty and Michel Dallaporta and Marc Foretz and Martine Emery and David Tarussio and Isabelle Bady and Christophe Binnert and Friedrich Beermann and Bernard Thorens},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 12},
  pages={3545-53}
}
Ripglut1;glut2-/- mice have no endogenous glucose transporter type 2 (glut2) gene expression but rescue glucose-regulated insulin secretion. Control of glucagon plasma levels is, however, abnormal, with fed hyperglucagonemia and insensitivity to physiological hypo- or hyperglycemia, indicating that GLUT2-dependent sensors control glucagon secretion. Here… CONTINUE READING